Emerging research suggests a compelling link between the keto diet and alterations in DNA methylation patterns. This intriguing dietary approach, characterized by high fat intake and restricted carbohydrate consumption, may profoundly influence gene expression by modifying the epigenome. While the precise mechanisms remain under investigation, stud
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nevertheless, we strongly advocate the use of plasma instead of serum in cirDNA methylation scientific tests, since the qualifications DNA could substantially influence the analytical outcomes. Use of bisulfite sequencing could be demanding. Bisulfite conversion decreases genome complexity to 3 nucleotides (apart from the relatively rare five mC),